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Ke dihydrotanshinone pepehi wau iā Helicobacter pylori, ʻaʻole hiki iā ia ke luku wale i ka biofilm, akā pepehi pū kekahi i nā bacteria i pili i ka biofilm, kahi e hoʻokani ai i ka "huki" Helicobacter pylori.

ʻO Bi Hongkai, Polofesa, Kula o ka Laau Lapaʻau, Ke Kula Nui Lapaʻau ʻo Nanjing

Hōʻike ka ʻike hou loa o ka maʻi ʻaʻai honua ma waena o nā 4.57 miliona mau maʻi ʻaʻai hou ma Kina i kēlā me kēia makahiki, 480,000 mau hihia hou o ka maʻi ʻaʻai gastric, e helu ana no 10.8%, i waena o nā mea ʻekolu. I Kina me ka nui o ka maʻi ʻōpū gastric, ʻo ka nui o ka maʻi ʻo Helicobacter pylori a hiki i ka 50%, a ʻo ka pilikia o ke kūpaʻa antibiotic e lilo ana i mea ʻoi aku ka koʻikoʻi, a laila e emi mau ana ka helu hoʻopau.
I kēia mau lā, ua kolo maikaʻi ʻia ke kime o Professor Bi Hongkai, School of Basic Medicine, Nanjing Medical University, i moho lāʻau hou no Helicobacter pylori-Dihydrotanshinone I. - Helicobacter pylori biofilm, palekana a me ke kūpaʻa ʻana i ke kūʻē ʻana, a pēlā aku, a e manaʻo ʻia e komo i ka noiʻi preclinical ma ke ʻano he moho lāʻau anti-Helicobacter pylori. Ua paʻi ʻia nā hopena ma ka pūnaewele i ka puke pai antimicrobial international international antimicrobial Agents a me Chemotherapy ".

ʻO ka helu mua o ka hana maikaʻi ʻole o nā hana kuʻuna ma kahi o 10%.

Ma lalo o ka microscope, 2.5 wale nō micrometers i ka 4 micrometers, a ʻo ka laulā he 0.5 micrometers wale nō i 1 micrometers. ʻO Helicobacter pylori, he koʻohune i kāwili ʻia e "hohola i nā māiʻuʻu a me nā hulahula", ʻaʻole hiki ke kumu wale i ka gastritis huehue a mau, gastric a me nā duodenal ulcer a me nā lymphatics. ʻO nā maʻi e like me ka lympoma gastric gastric pili pū kekahi me ka maʻi ʻaʻai gastric, ka maʻi ʻaʻai ate, a me ka maʻi kō.

Hoʻohana pinepine ʻia ka triple a me ka quadruple therapy i loko o koʻu ʻāina e mālama ai iā Helicobacter pylori, akā ʻaʻole hiki i nā hana kuʻuna maʻamau ke hoʻopau iā Helicobacter pylori.

"ʻO ka helu ʻole o ka mālama mua ʻia ʻana o ka hana kuʻuna ma kahi o 10%. E loaʻa i kekahi mau maʻi i ka maʻi diarrhea a i ʻole gastrointestinal flora. Hoʻopilikia kekahi i ka penicillin, a ʻoi aku ka liʻiliʻi o nā antibiotic e koho ai. I ka manawa like, ʻo ka hoʻohana lōʻihi ʻana o nā lāʻau ʻaloʻalo e hoʻopōpilikia ai i ka bacteria. ʻ saidlelo ʻo Bi Hongkai: Hoʻolahalaha ke koʻohune i kekahi i kekahi ma o nā ʻāpana kūpaʻa lāʻau, kahi e hoʻopilikia ai i ke kūpaʻa lāʻau ʻana o nā bacteria. ”

Ke pale aku ʻo Helicobacter pylori i ka hoʻouka kaua ʻana a ka ʻenemi, e hana maalea ʻo ia i kahi "uhi pale" biofilm nona iho, a e kūʻē ana ka biofilm i nā lāʻau ʻino, a laila e hoʻonui ana i ke kūʻē ʻana iā Helicobacter pylori, e hoʻopili ana i ka hopena a me ka hōʻemi ʻana i ka helu o ka hoʻōla.

Hiki i ka salvia miltiorrhiza extract cell ke hoʻokolohua ke pale i nā ʻano kūpaʻa lāʻau maha

I ka makahiki 1994, ua hoʻonohonoho ka World Health Organization iā Helicobacter pylori ma ke ʻano he carcinogen Class no ka mea he alakaʻi nui ia i ka hanana a me ka ulu ʻana o ka maʻi ʻaʻai gastric. Pehea e hoʻopau ai i kēia mea hoʻomake olakino? I ka makahiki 2017, ua holomua ka hui a Bi Hongkai ma o nā hoʻokolohua mua-Danshen.

ʻO Danshen kekahi o nā lāʻau lapaʻau Kina i hoʻohana nui ʻia no ka hāpai ʻana i ke kahe o ke koko a me ka lawe ʻana i ka stasis koko. ʻO kāna mau mea hoʻoheheʻe ʻia ka momona ka mea i hoʻohui ʻia me nā tanshinone, e like me 30 mau monomers e like me tanshinone I, dihydrotanshinone, tanshinone IIA, a me cryptotanshinone. Loaʻa i nā hui ʻo Thinhinone nā ʻano lāʻau like ʻole, e like me anti-cancer, anti-positive bacteria, anti-inflammatory, estrogen-like activity a me ka pale ʻana i ka maʻi puʻuwai, a pēlā aku, akā ʻaʻole i hōʻike ʻia ka hopena anti-Helicobacter pylori.

"Ma mua, ua nānā mākou he ʻoi aku ma mua o 1000 monomers lāʻau lapaʻau Kina ma ka pae o ka cell, a hoʻoholo hope loa ʻo ka dihydrotanshinone I monomer ma Danshen ka hopena maikaʻi loa i ka luku ʻana iā Helicobacter pylori. Ke hana nei i nā hoʻokolohua pūnaewele, ua ʻike mākou i ka hoʻohana ʻia ʻana o ka dihydrotanshinone I ka wā 0.125 μg / ml-0.5 μg / ml, hiki iā ia ke pale i ka ulu ʻana o nā ʻano pylori Helicobacter, me nā ʻano antibiotic-sensitive a me nā ʻano lāʻau kūpona nunui. . ” Ua ʻōlelo ʻo Bi Hongkai ʻo dihydrotanshinone I ka mea maikaʻi loa e kūʻē iā Helicobacter pylori i nā biofilms. ʻO ka hopena pepehi maikaʻi, a me Helicobacter pylori ʻaʻole i hoʻomohala i ke kūpaʻa i ka dihydrotanshinone I i ka manawa o ka hele mau.

ʻO ke kahaha nui ʻo "Ke dihydrotanshinone e pepehi wau iā Helicobacter pylori, ʻaʻole hiki iā ia ke luku wale i ka biofilm, akā pepehi pū kekahi i nā bacteria i pili i ka biofilm, kahi e hoʻokani nei i ka" root "Helicobacter pylori. "Ua hoʻolauna ʻo Bi Hongkai.

Hiki iā Dihydrotanshinone ke hoʻōla iā Helicobacter pylori?

I mea e ʻoi aku ai ka hopena o nā hopena hoʻokolohua, ua alakaʻi ka hui o Bi Hongkai i nā hoʻokolohua loiloi i nāʻiole e hoʻoholo hou ai i ka hopena pepehi o dihydrotanshinone I ma Helicobacter pylori.

Ua hōʻike ʻo Bi Hongkai i loko o ka hoʻokolohua, ʻelua mau pule ma hope o ka maʻi ʻana o nāʻiole me Helicobacter pylori, ua hoʻokaʻawale ʻanalike nā mea noiʻi iā lākou i ʻekolu mau hui, ʻo ia hoʻi ka hui hoʻomalu hui o omeprazole a me dihydrotanshinone I, ka hui hoʻomalu regimen regimen pae ʻekolu, a me ka phosphoric acid In ka pūʻulu mālama buffer, hāʻawi ʻia nā ʻiole i ka lāʻau i hoʻokahi manawa i ka lā no 3 mau lā.

"Hōʻike nā hopena hoʻokolohua i ka hui hoʻomalu hui o omeprazole a me dihydrotanshinone I he ʻoi aku ka maikaʻi ma ka pepehi ʻana iā Helicobacter pylori ma mua o ka pūʻulu regiple maʻamau." Ua ʻōlelo ʻo Bi Hongkai, ʻo ia hoʻi i nāʻiole, dihydrotanshinone he ʻoi aku ka kiʻekiʻe o ka make ma mua o nā lāʻau kuʻuna.

Āhea e komo ai ʻo Dihydrotanshinone I i nā hale o ka poʻe maʻamau? Ua hoʻomaopopo ʻo Bi Hongkai ʻaʻole hiki ke hoʻohana pololei ʻia ʻo Danshen e pale a mālama iā Helicobacter pylori maʻi, a ʻo kāna monomer dihydrotanshinone I kahi lōʻihi loa ia mai ka lilo ʻana i lāʻau e hiki ke hoʻohana ʻia me ka lāʻau lapaʻau. Ua ʻōlelo ʻo ia e hoʻomau ka hana hou i ke ʻano o ka hana o dihydrotanshinone I, a hoʻomaikaʻi i ka lāʻau a me ka lāʻau ʻona o dihydrotanshinone I e kūʻē iā Helicobacter pylori. “Lōʻihi nō ke ala i mua. Lana koʻu manaʻo e hiki i nā ʻoihana ke komo i ka noiʻi pre-clinical a hoʻomau i kēia noiʻi e pono ai nā mea maʻi hou aʻe me nā maʻi ʻōpū. ”